Tom Radisch attended the Academy of Music and Theatre in Rostock from 2006 to 2007. From 2007 to 2011 he studied acting at the Hochschule für Schauspielkunst "Ernst Busch" in Berlin.

He had his first theatre engagements during his studies, for example at the Deutsches Theater Berlin as Laertes in Hamlet, directed by Andreas Kriegenburg, at the Schaubühne Berlin in Berlin Alexanderplatz, directed by Volker Lösch, and as Karl Schmidt at the bat-Studiotheater in Der kleine Bruder, directed by Leander Haußmann and Sven Regener. For this role he was awarded the "Ensemble Prize" at the Theatertreffen der Schauspielschulen in Leipzig.

From 2011 to 2015 he was part of the ensemble of the Residenztheater in Munich. There he worked with Radu Afrim, Tina Lanik, Thomas Birkmeir, Walter Meierjohann, Herbert Fritsch, Yannis Houvardas, Barbara Weber and Martin Kusej, among others.

In 2015 he appeared at the Nibelungen Festival Worms (artistic director: Nico Hofmann) as Volker von Alzey in the world premiere of the play "Gemetzel" by Albert Ostermaier. From 2017 to 2019 he was on stage as Grimbald in the celebrated semi-opera production of "King Arthur" by Sven Eric Bechtolf at the Berlin Staatsoper unter den Linden. Since 2020, Tom Radisch has made a guest appearance at Schauspiel Köln, where he can be seen in the German premiere of Elfriede Jelinek's "Schwarzwasser", directed by Stefan Bachmann. In December 2020, the production was adapted for the camera under the title "Schwarzwasser der Film".

Parallel to his theatre work, Tom Radisch is regularly in front of the camera.