In 2015, Sofia received a leading role alongside Wotan Wilke Möhring in the film Kleine Ziege, sturer Bock. In 2016, she appeared in the film Conni & Co.

In addition to acting, Sofia Bolotina is active as a gymnast and used to train at the Horner TV. She is skilled in contortion and is a floor gymnast as well as a handstand acrobat. In 2013, she performed with the Hamburg ShowSternchen of Horner TV at the RTL Supertalent show. Since the age of seven, Bolotina has also worked as a model.

In 2019, Sofia began pursuing music. Since March 2021, she has been signed to "Bela Boyz," a label by rapper Veysel. On September 9, 2021, her first single was released. The remix "Ohne Dich" by Veysel ft. Sofia Bolotina quickly gained over 6.5 million streams on Spotify. The song is also featured on Veysel's album Hitman 2, which was released on November 12, 2021.

In 2023, Sofia played the role of Dunja in the ARD series Asbest, which reached number 1 in the German series charts on Netflix.

In 2024, she appeared in a guest role in "Polizeiruf Rostock". 

In 2025, a trailer for the horror-comedy "Bitten Soon" was released, and the full film is planned for production next year.